The arrest of Wilson Fisk was supposed to bring peace to Manhattan, but it only opened the door for a new, more chaotic brand of lawlessness. As Peter Parker balances a failing scientific career with the weight of a city's survival, he discovers that his mentor's brilliance might be hiding a dangerous desperation. The shadows are lengthening over New York, and the man behind the mask is starting to realize that some webs are too tangled for even him to unknot.