What happens when a trauma surgeon applies the 'invert, always invert' philosophy to a healthcare system that consumes 21% of the U.S. GDP? Niral Shah reveals how the decoupling of buyers and end-users has created a trillion-dollar inefficiency that is finally reaching its breaking point. From dodging existential 'bullets' in the startup world to treating aging as a manageable condition, Shah provides a blueprint for the coming era of medical disintermediation and why the 'organ donation' of a failing company might be the most honorable move a founder can make.