In an era obsessed with data and rationality, why are we experiencing a global crisis of purpose? Dr. Clay Routledge argues that our brains are biologically wired to require meaning as a defense against the unique human awareness of death. By shifting from a culture of victimhood to one of 'existential agency,' we can reclaim our power to build a significant life through mattering, nostalgia, and a balanced embrace of both scientific logic and spiritual intuition.